7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate

7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate

Nitric oxide (NO) plays a pivotal role in integrating dopamine transmission in the basal ganglia and has been implicated in the pathogenesis of Parkinson disease (PD). The objective of this study was to ascertain whether the NO synthase inhibitor, 7-nitroindazole (7-NI), is able to reduce L-DOPA-ind...

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Bibliographic Details
Main Authors: M. T. Herrero, J. E. Yuste, L. Cuenca-Bermejo, P. Almela, L. Arenas-Betancur, V. De Pablos, A. Gonzalez-Cuello, E. Del Bel, J. Navarro-Zaragoza, E. Fernández-Villalba
Format: Article
Language:English
Published: The Royal Society 2023-05-01
Series:Open Biology
Subjects:
Parkinson's disease
NO
7-NI
dyskinesias
L-DOPA
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.220370

Internet

https://royalsocietypublishing.org/doi/10.1098/rsob.220370

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