The potential of PARP inhibitors in targeted cancer therapy and immunotherapy

The potential of PARP inhibitors in targeted cancer therapy and immunotherapy

DNA damage response (DDR) deficiencies result in genome instability, which is one of the hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various DDR pathways, determining cell fate in the wake of DNA damage. PARPs are readily druggable and PARP inhibitors (PARPi) agains...

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Bibliographic Details
Main Authors: Jaromir Hunia, Karol Gawalski, Aleksandra Szredzka, Marcin J. Suskiewicz, Dominika Nowis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
PARP inhibitors
immune checkpoint inhibitors
immunotherapy
synthetic lethality
DNA repair
BRCA
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1073797/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.1073797/full

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