A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase

A new negative feedback mechanism for MAPK pathway inactivation through Srk1 MAPKAP kinase

Abstract The fission yeast mitogen-activated kinase (MAPK) Sty1 is essential for cell survival in response to different environmental insults. In unstimulated cells, Sty1 forms an inactive ternary cytoplasmatic complex with the MAPKK Wis1 and the MAPKAP kinase Srk1. Wis1 phosphorylates and activates...

Full description

Bibliographic Details
Main Authors: Maribel Marquina, Eva Lambea, Mercé Carmona, Marta Sánchez-Marinas, Sandra López-Aviles, José Ayte, Elena Hidalgo, Rosa Aligue
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23970-8

Internet

https://doi.org/10.1038/s41598-022-23970-8

Similar Items