Development and Evaluation of 2-Amino-7-Fluorophenazine 5,10-Dioxide Polymeric Micelles as Antitumoral Agents for 4T1 Breast Cancer

Development and Evaluation of 2-Amino-7-Fluorophenazine 5,10-Dioxide Polymeric Micelles as Antitumoral Agents for 4T1 Breast Cancer

2-Amino-7-fluorophenazine 5,10-dioxide (FNZ) is a bioreducible prodrug, poorly soluble in water, with potential anticancer activity on hypoxic-tumors. This poor solubility limits its potential applications in clinic. Amphiphilic pristine polymeric micelles (PMs) based on triblock copolymers Pluronic...

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Bibliographic Details
Main Authors: Nicole Lecot, Belén Dávila, Carina Sánchez, Marcelo Fernández, Mercedes González, Pablo Cabral, Hugo Cerecetto, Romina Glisoni
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Polymers
Subjects:
bioreductive-drug
phenazine-5,10-dioxide
amphiphilic pristine polymeric micelles
4T1-tumor model
in vivo antitumoral activity
Online Access:https://www.mdpi.com/2073-4360/14/1/71

Internet

https://www.mdpi.com/2073-4360/14/1/71

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