Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux

Blunting ROS/TRPML1 pathway protects AFB1-induced porcine intestinal epithelial cells apoptosis by restoring impaired autophagic flux

Aflatoxin B1 (AFB1) is a stable mycotoxin that contaminates animal feed on a large scale and causes severe damage to intestinal cells, induces inflammation and stimulates autophagy. Transient receptor potential mucolipin subfamily 1 (TRPML1) is a regulatory factor of autophagy, but the underlying me...

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Bibliographic Details
Main Authors: Xinyi Cheng, Jiahua Liang, Dan Wu, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Ping Liu, Ruiming Hu, Guoliang Hu, Yu Zhuang
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Aflatoxin B1
TRPML1
ROS
Autophagic flux
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323004463

Internet

http://www.sciencedirect.com/science/article/pii/S0147651323004463

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