G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion

G Protein-Coupled Receptor 109A Maintains the Intestinal Integrity and Protects Against ETEC Mucosal Infection by Promoting IgA Secretion

Several studies have reported an intricate link between the G protein-coupled receptor 109A (GPR109A) and intestinal health. Upon activation, induced by butyric acid and β-hydroxybutyric acid, GPR109A regulates the expression of tight junction proteins, exerts anti-inflammatory effects, and maintain...

Full description

Bibliographic Details
Main Authors: Yuhong Gong, Xinxin Jin, Boyu Yuan, Yantao Lv, Guangmou Yan, Mingming Liu, Changxin Xie, Juxiong Liu, Yimei Tang, Hongyan Gao, Yufeng Zhu, Yanhua Huang, Wei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
GPR109A
enterotoxigenic Escherichia coli
secretory IgA
epithelium barrier
sodium butyrate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583652/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.583652/full

Similar Items