Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

Resuscitation in Paediatric Sepsis Using Metabolic Resuscitation–A Randomized Controlled Pilot Study in the Paediatric Intensive Care Unit (RESPOND PICU): Study Protocol and Analysis Plan

Introduction: Septic shock remains amongst the leading causes of childhood mortality. Therapeutic options to support children with septic shock refractory to initial resuscitation with fluids and inotropes are limited. Recently, the combination of intravenous hydrocortisone with high dose ascorbic a...

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Bibliographic Details
Main Authors: Luregn J. Schlapbach, Kristen Gibbons, Roberta Ridolfi, Amanda Harley, Michele Cree, Debbie Long, David Buckley, Simon Erickson, Marino Festa, Shane George, Megan King, Puneet Singh, Sainath Raman, Rinaldo Bellomo, The RESPOND PICU study investigators and the Australian New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pediatrics
Subjects:
ascorbic acid
child
hydrocortisone
intensive care
sepsis
septic shock
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.663435/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.663435/full

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