Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis

Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis

Colitis-associated colon cancer (CAC) accompanies the massive infiltration of neutrophils during tumorigenesis and progression of CAC. Depletion of neutrophils in circulation results in significant inhibition of tumor incidence in CAC. However, the underlying mechanisms are largely unclear. In this...

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Bibliographic Details
Main Authors: Qing Cai, Minsun Kim, Aki Harada, Michael O. Idowu, Gobalakrishnan Sundaresan, Jamal Zweit, Youngman Oh
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
colitis-associated colon cancer
AAT
neutrophil
NSPs
IGFBP-3
IGFBP-3R
Online Access:https://www.mdpi.com/1422-0067/23/22/13737

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https://www.mdpi.com/1422-0067/23/22/13737

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