Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19

Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19

Objectives: We investigated the expression of toll-like receptor (TLR)-4 on the cell surface of innate and adaptive cells from patients with COVID-19 carrying the rs4986790 GG genotype in the TLR4 gene and the functional profile of these cells. Methods: We included 1169 hospitalized patients with CO...

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Bibliographic Details
Main Authors: Julio Flores-Gonzalez, Leslie Chavez-Galan, Ramcés Falfán-Valencia, Ivette Buendía Roldán, Ingrid Fricke-Galindo, Abigail Veronica-Aguilar, Alfonso Martínez-Morales, Rafael de Jesús Hernández-Zenteno, Iris Paola Guzmán-Guzmán, Gloria Pérez-Rubio
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:International Journal of Infectious Diseases
Subjects:
TLR4
COVID-19
Polymorphism
CD8+ T cell
B cell
Monocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971223007932

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http://www.sciencedirect.com/science/article/pii/S1201971223007932

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