Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19

Variant rs4986790 of toll-like receptor 4 affects the signaling and induces cell dysfunction in patients with severe COVID-19

Objectives: We investigated the expression of toll-like receptor (TLR)-4 on the cell surface of innate and adaptive cells from patients with COVID-19 carrying the rs4986790 GG genotype in the TLR4 gene and the functional profile of these cells. Methods: We included 1169 hospitalized patients with CO...

Full description

Bibliographic Details
Main Authors:	Julio Flores-Gonzalez, Leslie Chavez-Galan, Ramcés Falfán-Valencia, Ivette Buendía Roldán, Ingrid Fricke-Galindo, Abigail Veronica-Aguilar, Alfonso Martínez-Morales, Rafael de Jesús Hernández-Zenteno, Iris Paola Guzmán-Guzmán, Gloria Pérez-Rubio
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	International Journal of Infectious Diseases
Subjects:	TLR4 COVID-19 Polymorphism CD8+ T cell B cell Monocytes
Online Access:	http://www.sciencedirect.com/science/article/pii/S1201971223007932

Similar Items

Role of rs4986790 Polymorphism of TLR4 Gene in Susceptibility towards Malaria Infection in the Pakistani Population
by: Asima RANI, et al.
Published: (2018-05-01)

Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4
by: Nathalie Guriec, et al.
Published: (2018-11-01)

The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19
by: Daniela Valencia-Pérez Rea, et al.
Published: (2023-06-01)

The Role of Toll-like Receptor 2 (TLR2) in the Development and Progression of Hashimoto’s Disease (HD): A Case Study on Female Patients in Poland
by: Maria Klatka, et al.
Published: (2023-03-01)

Strong Association of the rs4986790 Single Nucleotide Polymorphism (SNP) of the Toll-Like Receptor 4 (<i>TLR4</i>) Gene with Human Immunodeficiency Virus (HIV) Infection: A Meta-Analysis
by: Yong-Chan Kim, et al.
Published: (2020-12-01)

Editorial: Translational research in severe COVID-19 and long-term symptoms post-COVID-19
by: Vanesa Vicens-Zygmunt, et al.
Published: (2023-09-01)

Hemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling
by: José M. Rojas, et al.
Published: (2021-12-01)

The relationship between 896A/G (rs4986790) polymorphism of TLR4 and infectious diseases: A meta-analysis
by: Marcos Jessé Abrahão Silva, et al.
Published: (2022-11-01)

Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients
by: Salim F, et al.
Published: (2023-01-01)

Distinguishing naive‐ from memory‐derived human B cells during acute responses
by: Maria Auladell, et al.
Published: (2019-01-01)

TLR expression in peripheral monocyte subsets of patients with idiopathic inflammatory myopathies: association with clinical and immunological features
by: Jiram Torres-Ruiz, et al.
Published: (2020-03-01)

Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
by: Siv H. Moen, et al.
Published: (2019-05-01)

Bacterial Protein Toll-Like-Receptor Agonists: A Novel Perspective on Vaccine Adjuvants
by: Sudeep Kumar, et al.
Published: (2019-05-01)

Outcome predictors in COVID-19: An analysis of emergent systemic inflammation indices in Mexican population
by: Ilse Adriana Gutiérrez-Pérez, et al.
Published: (2022-10-01)

Çeşitli Hastalıklarda Toll Benzeri Reseptörlerin Rolü
by: Berrak Güven, et al.
Published: (2012-03-01)

COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in <i>MUC5B</i> Have Higher Plasma Levels of Mucin 5B
by: Salvador García-Carmona, et al.
Published: (2022-07-01)

Analysis of Association of Asp299Gln (rs 4986790) and Thr399Ile (rs 4986791) Polymorphisms of the <i>TLR4</i> Gene with Risk of Developing Lung Sarcoidosis (Using the Example of Residents of Karelia)
by: I. E. Malysheva, et al.
Published: (2022-10-01)

Stimulation of monocytes by placental microparticles involves Toll-like receptors and nuclear factor kappa-light-chain-enhancer of activated B cells
by: Marianne Simone Joerger-Messerli, et al.
Published: (2014-04-01)

The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19)
by: Christoph Zacher, et al.
Published: (2024-02-01)

Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14
by: Lucía Sanjurjo, et al.
Published: (2023-05-01)

Systemic bacterial infections affect dendritic cell development and function
by: Kristin Bieber, et al.
Published: (2021-08-01)

Toll-like receptors 7 and 9 regulate the proliferation and differentiation of B cells in systemic lupus erythematosus
by: Luyao Wen, et al.
Published: (2023-02-01)

Scratching the Surface Takes a Toll: Immune Recognition of Viral Proteins by Surface Toll-like Receptors
by: Alexis A. Hatton, et al.
Published: (2022-12-01)

High levels of PF4, VEGF-A, and classical monocytes correlate with the platelets count and inflammation during active tuberculosis
by: Alexia Urbán-Solano, et al.
Published: (2022-10-01)

The <i>ACE</i> rs1799752 Variant Is Associated with COVID-19 Severity but Is Independent of Serum ACE Activity in Hospitalized and Recovered Patients
by: Ingrid Fricke-Galindo, et al.
Published: (2023-04-01)

A Single-Stranded Oligonucleotide Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection
by: Candice Poux, et al.
Published: (2019-09-01)

Pharmacogenetics Approach for the Improvement of COVID-19 Treatment
by: Ingrid Fricke-Galindo, et al.
Published: (2021-03-01)

Genetics Insight for COVID-19 Susceptibility and Severity: A Review
by: Ingrid Fricke-Galindo, et al.
Published: (2021-04-01)

B Cell Toll-like Receptors with Respect to the Pathogenesis of Sjögren’s Syndrome
by: Irena Berglová, et al.
Published: (2011-01-01)

The effect of Kagocel® on gene expression of Toll-like receptors of innate immunity in THP-1 human monocytes with different levels of differentiation
by: T. M. Sokolova, et al.
Published: (2021-07-01)

Association of PADI2 and PADI4 polymorphisms in COVID-19 host severity and non-survival
by: Ilse Adriana Gutiérrez-Pérez, et al.
Published: (2024-03-01)

Association of Toll‐like 4 receptor gene polymorphism (rs4986790, rs4986791) with the risk of urinary tract infection: A systematic review and meta‐analysis
by: Wen‐Lin Huang, et al.
Published: (2020-03-01)

Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells
by: Jonathan Lagos, et al.
Published: (2022-12-01)

The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
by: JI Ling, et al.
Published: (2021-02-01)

TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity
by: William D Jackson, et al.
Published: (2023-08-01)

Toll-like receptor 4 deficiency impairs motor coordination.
by: Jianwei eZhu, et al.
Published: (2016-02-01)

The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9
by: Alexander Möller, et al.
Published: (2023-03-01)

Study of polymorphism of toll like receptor-4 gene in crossbred cattleand its association with somatic cell count
by: S M SONWANE, et al.
Published: (2023-12-01)

Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication?
by: Matylda Barbara Mielcarska, et al.
Published: (2021-02-01)

Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade
by: Chang Youp Ok, et al.
Published: (2023-07-01)