Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families

Rare Pathogenic Variants in Genes Implicated in Glutamatergic Neurotransmission Pathway Segregate with Schizophrenia in Pakistani Families

Schizophrenia is a disabling neuropsychiatric disorder of adulthood onset with high heritability. Worldwide collaborations have identified an association of ~270 common loci, with small individual effects and hence weak clinical implications. The recent technological feasibility of exome sequencing...

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Bibliographic Details
Main Authors: Ambrin Fatima, Uzma Abdullah, Muhammad Farooq, Yuan Mang, Mana M. Mehrjouy, Maria Asif, Zafar Ali, Niels Tommerup, Shahid M. Baig
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Genes
Subjects:
familial schizophrenia
duplication
rare variants
glutamatergic neurotransmission
Online Access:https://www.mdpi.com/2073-4425/12/12/1899

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https://www.mdpi.com/2073-4425/12/12/1899

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