Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro

Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro

Abstract Background Pulmonary fibrosis is a progressive disease characterized by lung remodeling due to excessive deposition of extracellular matrix. Although the etiology remains unknown, aberrant angiogenesis and inflammation play an important role in the development of this pathology. In this con...

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Bibliographic Details
Main Authors: Laura Cucinotta, Deborah Mannino, Giovanna Casili, Alberto Repici, Lelio Crupi, Irene Paterniti, Emanuela Esposito, Michela Campolo
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis
Prolyl oligopeptidase
Bleomycin
Angiogenesis
Inflammatory
Online Access:https://doi.org/10.1186/s12931-023-02519-x

Internet

https://doi.org/10.1186/s12931-023-02519-x

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