Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

Summary: Peripheral inflammation has been linked to various neurodegenerative disorders, including Alzheimer’s disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in APP/PS1 mice intranasally exposed to Staphylococcus aureus to determine how low-grade peripheral infection af...

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Bibliographic Details
Main Authors: Yi Lu, Carolina Saibro-Girardi, Nicholas Francis Fitz, Mikayla Ranae McGuire, Mary Ann Ostach, A.N.M. Mamun-Or-Rashid, Iliya Lefterov, Radosveta Koldamova
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723007969

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http://www.sciencedirect.com/science/article/pii/S2211124723007969

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