Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization

Abstract ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disease characterized by the redistribution of the RNA binding protein TDP-43 in affected neurons: from predominantly nuclear to aggregated in the cytosol. However, the determinants of TDP-43 localization and the cellular insults th...

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Bibliographic Details
Main Authors: Emile S. Pinarbasi, Tolga Cağatay, Ho Yee Joyce Fung, Ying C. Li, Yuh Min Chook, Philip J. Thomas
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25008-4

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https://doi.org/10.1038/s41598-018-25008-4

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