Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expression pathway analysis was used to compare the functio...

Full description

Bibliographic Details
Main Authors: Hosni Cherif, Daniel G Bisson, Matthew Mannarino, Oded Rabau, Jean A Ouellet, Lisbet Haglund
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
intervertebral disc
cartilage
nucleus pulposus
annulus fibrosus
Online Access:https://elifesciences.org/articles/54693

Internet

https://elifesciences.org/articles/54693

Similar Items