Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae

Evolution of ceftazidime–avibactam resistance driven by mutations in double-copy blaKPC-2 to blaKPC-189 during treatment of ST11 carbapenem-resistant Klebsiella pneumoniae

ABSTRACT Klebsiella pneumoniae carbapenemase (KPC) variants can contribute to resistance to ceftazidime–avibactam (CZA) in Klebsiella pneumoniae (KP). However, two-copy KPC variant-mediated resistance to CZA has rarely been reported to date. Here, we aimed to clarify the evolutionary trajectory of C...

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Bibliographic Details
Main Authors: Xiaofan Zhang, Yinrong Xie, Ying Zhang, Tailong Lei, Longjie Zhou, Jiayao Yao, Lin Liu, Haiyang Liu, Jintao He, Yunsong Yu, Yuexing Tu, Xi Li
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mSystems
Subjects:
ST11
CRKP
blaKPC-189
double-copy
CZA resistance
Online Access:https://journals.asm.org/doi/10.1128/msystems.00722-24

Internet

https://journals.asm.org/doi/10.1128/msystems.00722-24

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