Persistent Lipid Accumulation Leads to Persistent Exacerbation of Endoplasmic Reticulum Stress and Inflammation in Progressive NASH via the IRE1α/TRAF2 Complex

Persistent Lipid Accumulation Leads to Persistent Exacerbation of Endoplasmic Reticulum Stress and Inflammation in Progressive NASH via the IRE1α/TRAF2 Complex

Non-alcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to other severe liver diseases, yet treatment options are limited. Endoplasmic reticulum (ER) stress is an important pathogenetic mechanism of NASH and plays a key role in tandem steatosis as well as liver inflammation. Th...

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Bibliographic Details
Main Authors: Na Lei, Hongfei Song, Ling Zeng, Shaoxiu Ji, Xiangbo Meng, Xiuying Zhu, Xiuyan Li, Quansheng Feng, Jibin Liu, Jie Mu
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
non-alcoholic steatohepatitis
lipid accumulation
endoplasmic reticulum stress
IRE1α/TRAF2 complex
IKK/IκB/NF-κB signaling pathway
ASK1/JNK1 signaling pathway
Online Access:https://www.mdpi.com/1420-3049/28/7/3185

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https://www.mdpi.com/1420-3049/28/7/3185

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