Marked Mild Cognitive Deficits in Humanized Mouse Model of Alzheimer’s-Type Tau Pathology

Hyperphosphorylation and the subsequent aggregation of tau protein into neurofibrillary tangles (NFTs) are well-established neuropathological hallmarks of Alzheimer’s disease (AD) and associated tauopathies. To further examine the impact and progression of human tau pathology in neurodegenerative co...

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Bibliographic Details
Main Authors: Joshua D. Cho, Yoon A. Kim, Elizabeth E. Rafikian, Mu Yang, Ismael Santa-Maria
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.634157/full