Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L. Defects in the Fas-mediated apoptotic pathway have been reported in colorectal cancer.In the present study, a variant of the Apc(Min/+) mouse, a model for the human condit...

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Bibliographic Details
Main Authors: Hector Guillen-Ahlers, Mark A Suckow, Francis J Castellino, Victoria A Ploplis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2816700?pdf=render