Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Abstract Background The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies. Methods To determine whether convalescent or standard plasma would improve...

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Bibliographic Details
Main Authors: Paola Maria Manzini, Giovannino Ciccone, Francesco Giuseppe De Rosa, Rossana Cavallo, Valeria Ghisetti, Sergio D’Antico, Claudia Galassi, Fabio Saccona, Anna Castiglione, Nadia Birocco, Tiziana Francisci, Huijing Hu, Clara Pecoraro, Franca Danielle, Luciana Labanca, Anna Maria Bordiga, Marco Lorenzi, Giovanni Camisasca, Osvaldo Giachino, Mauro Pagliarino, Piero Ottone, Ilvana Tiziana Donatella Scuvera, Roberto Guaschino, Roberto Freilone, Pierluigi Berti, Fabrizia Pittaluga, Maria Avolio, Cristina Costa, Samuele Raso, Aurora Nucci, Massimo Milan, Alessandra Baffa, Alessandra Russo, Antonella Tornello, Laura Maddalena, Grazia Delios, Fabio Paolo Marletto, Anna Grazia De Micheli, Alessio Mattei, Stefano Baldassano, Francesca Canta, Maria Luisa Russo, Daniele Bergamo, Francesco Vitale, Marco Maria Liccardi, Alessandra Chinaglia, Andrea Calcagno, Marcella Converso, Chiara Aldieri, Valentina Libanore, Ilaria Blangetti, Valentina Benedetti, Barbara Mitola, Gitana Scozzari, the PLACO COVID Study Group
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Infectious Diseases
Subjects:
COVID-19 therapy
COVID-19 convalescent plasma
COVID-19 outcomes
Randomized clinical trial
Online Access:https://doi.org/10.1186/s12879-022-07716-5

Internet

https://doi.org/10.1186/s12879-022-07716-5

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