Beauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathway.

Crohn's disease is a common, chronic inflammatory bowel condition characterized by remission and relapse. Accumulating evidence indicates that activated T cells play an important role in this disease. In the present study, we aimed to examine the effect of beauvericin, a natural cyclic peptide,...

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Bibliographic Details
Main Authors: Xue-Feng Wu, Rui Xu, Zi-Jun Ouyang, Cheng Qian, Yan Shen, Xu-Dong Wu, Yan-Hong Gu, Qiang Xu, Yang Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3858350?pdf=render