Alterations in metal homeostasis occur prior to canonical markers in Huntington disease

Abstract The importance of metal biology in neurodegenerative diseases such as Huntingtin Disease is well documented with evidence of direct interactions between metals such as copper, zinc, iron and manganese and mutant Huntingtin pathobiology. To date, it is unclear whether these interactions are...

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Bibliographic Details
Main Authors: Anna C. Pfalzer, Yan Yan, Hakmook Kang, Melissa Totten, James Silverman, Aaron B. Bowman, Keith Erikson, Daniel O. Claassen
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-14169-y