Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions
Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, functi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-93775-8 |
| _version_ | 1818433979371487232 |
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| author | Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin |
| author_facet | Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin |
| author_sort | Silvana Valdebenito |
| collection | DOAJ |
| description | Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor. |
| first_indexed | 2024-12-14T16:29:42Z |
| format | Article |
| id | doaj.art-e0d2633ce8134bc0b579ada8b11a03c8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T16:29:42Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e0d2633ce8134bc0b579ada8b11a03c82022-12-21T22:54:37ZengNature PortfolioScientific Reports2045-23222021-07-0111111810.1038/s41598-021-93775-8Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditionsSilvana Valdebenito0Shaily Malik1Ross Luu2Olivier Loudig3Megan Mitchell4George Okafo5Krishna Bhat6Brendan Prideaux7Eliseo A. Eugenin8Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB)Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB)Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB)Center for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthGO Pharma-Consulting Ltd.Department of Translational Molecular Pathology, Division of Pathology and Laboratory Medicine, M.D. AndersonDepartment of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB)Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch (UTMB)Abstract Cell-to-cell communication is essential for the development and proper function of multicellular systems. We and others demonstrated that tunneling nanotubes (TNT) proliferate in several pathological conditions such as HIV, cancer, and neurodegenerative diseases. However, the nature, function, and contribution of TNT to cancer pathogenesis are poorly understood. Our analyses demonstrate that TNT structures are induced between glioblastoma (GBM) cells and surrounding non-tumor astrocytes to transfer tumor-derived mitochondria. The mitochondrial transfer mediated by TNT resulted in the adaptation of non-tumor astrocytes to tumor-like metabolism and hypoxia conditions. In conclusion, TNT are an efficient cell-to-cell communication system used by cancer cells to adapt the microenvironment to the invasive nature of the tumor.https://doi.org/10.1038/s41598-021-93775-8 |
| spellingShingle | Silvana Valdebenito Shaily Malik Ross Luu Olivier Loudig Megan Mitchell George Okafo Krishna Bhat Brendan Prideaux Eliseo A. Eugenin Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions Scientific Reports |
| title | Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| title_full | Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| title_fullStr | Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| title_full_unstemmed | Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| title_short | Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| title_sort | tunneling nanotubes tnt communicate glioblastoma with surrounding non tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions |
| url | https://doi.org/10.1038/s41598-021-93775-8 |
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