The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression

The Antidepressant-Like Effects of a Clinically Relevant Dose of Ketamine Are Accompanied by Biphasic Alterations in Working Memory in the Wistar Kyoto Rat Model of Depression

Major depressive disorder (MDD) is the leading cause of disability worldwide. The majority of antidepressant drugs require several weeks or months of treatment to demonstrate efficacy and a subset of patients are resistant to such interventions. Ketamine demonstrates rapid and long-lasting antidepre...

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Bibliographic Details
Main Authors: Conor W. McDonnell, Fionn Dunphy-Doherty, Jennifer Rouine, Massimiliano Bianchi, Neil Upton, Ewa Sokolowska, Jack A. Prenderville
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Psychiatry
Subjects:
animal model
antidepressant
ketamine
plasma exposure
working memory
Wistar Kyoto
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2020.599588/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2020.599588/full

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