Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction.

Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction.

<h4>Background</h4>In chronic liver disease, hepatic stellate cells (HSC) transdifferentiate into myofibroblasts, promoting extracellular matrix (ECM) synthesis and deposition. Stimulation of HSC by transforming growth factor-β (TGF-β) is a crucial event in liver fibrogenesis due to its...

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Bibliographic Details
Main Authors: Monika Kwiecinski, Andrea Noetel, Natalia Elfimova, Jonel Trebicka, Stephanie Schievenbusch, Ingo Strack, Levente Molnar, Melanie von Brandenstein, Ulrich Töx, Roswitha Nischt, Oliver Coutelle, Hans Peter Dienes, Margarete Odenthal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931759/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931759/pdf/?tool=EBI

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