Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes

Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress and Insulin Resistance Are Prevented by Imoxin in C2C12 Myotubes

In obesity, plasma free fatty acids (FFAs) levels are elevated due to enlarged adipose tissue mass. Saturated fatty acids can induce prolonged ER stress and insulin resistance. Double-stranded RNA-dependent Protein Kinase (PKR) is activated under stress conditions in skeletal muscle. The current stu...

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Bibliographic Details
Main Authors: Hyeyoon Eo, Rudy J Valentine
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Physiology
Subjects:
imoxin
PKR
palmitate
ER stress
insulin signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.842819/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.842819/full

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