Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability

Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability

The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression. It is involved in the control of the cell cycle, chromatin modific...

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Bibliographic Details
Main Authors: Nafiseh Chalabi Hagkarim, Morteza Chalabi Hajkarim, Toru Suzuki, Toshinobu Fujiwara, G. Sebastiaan Winkler, Grant S. Stewart, Roger J. Grand
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
CNOT complex
CNOT1
CNOT7
CNOT8
genome instability
DNA repair
Online Access:https://www.mdpi.com/2073-4409/12/14/1868

Internet

https://www.mdpi.com/2073-4409/12/14/1868

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