Thyrotropin Regulates eNOS Expression in the Endothelium by PGRN Through Akt Pathway

Thyrotropin Regulates eNOS Expression in the Endothelium by PGRN Through Akt Pathway

To investigate the expression of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) in the aorta of subclinical hypothyroidism (SCH) rat model. The mechanisms underlying thyrotropin (TSH) affecting eNOS and PGRN expression in human umbilical vein endothelial cells (HUVECs) cultured in vi...

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Bibliographic Details
Main Authors: Fengwei Jiang, Haoyu Wang, Suqing Bao, Haicheng Zhou, Yuanyuan Zhang, Yumeng Yan, Yaxin Lai, Weiping Teng, Zhongyan Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Endocrinology
Subjects:
subclinical hypothyroidism
thyrotropin
endothelial nitric oxide synthase
progranulin
human umbilical vein endothelial cells
Akt
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00353/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00353/full

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