Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model

Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model

IntroductionLeaky gut has been linked to autoimmune disorders including lupus. We previously reported upregulation of anti-flagellin antibodies in the blood of lupus patients and lupus-prone mice, which led to our hypothesis that a leaky gut drives lupus through bacterial flagellin-mediated activati...

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Bibliographic Details
Main Authors: Razan M. Alajoleen, David N. Oakland, Rana Estaleen, Aida Shakeri, Ran Lu, Michael Appiah, Sha Sun, Jonathan Neumann, Shimako Kawauchi, Thomas E. Cecere, Ryan P. McMillan, Christopher M. Reilly, Xin M. Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
lupus
TLR5
glomerulonephritis
lymphoproliferation
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359534/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359534/full

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