BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection

BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection

Summary: Basic leucine zipper ATF-like transcription factor 2 (BATF2), an interferon-activated immune response regulator, is a key factor responsible for myeloid differentiation and depletion of HSC during chronic infection. To delineate the mechanism of BATF2 function in HSCs, we assessed Batf2 KO...

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Bibliographic Details
Main Authors: Duy T. Le, Marcus A. Florez, Pawel Kus, Brandon T. Tran, Bailee Kain, Yingmin Zhu, Kurt Christensen, Antrix Jain, Anna Malovannaya, Katherine Y. King
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Biological sciences
Molecular physiology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001360

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http://www.sciencedirect.com/science/article/pii/S2589004223001360

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