Maternal Metformin Treatment Reprograms Maternal High-Fat Diet-Induced Hepatic Steatosis in Offspring Associated with Placental Glucose Transporter Modifications

Maternal Metformin Treatment Reprograms Maternal High-Fat Diet-Induced Hepatic Steatosis in Offspring Associated with Placental Glucose Transporter Modifications

Maternal high-fat (HF) diet exposure in utero may affect fetal development and cause metabolic problems throughout life due to lipid dysmetabolism and oxidative damage. Metformin has been suggested as a potential treatment for body weight reduction and nonalcoholic fatty liver disease, but its repro...

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Bibliographic Details
Main Authors: Chien-Fu Huang, Mao-Meng Tiao, I-Chun Lin, Li-Tung Huang, Jiunn-Ming Sheen, You-Lin Tain, Chien-Ning Hsu, Ching-Chou Tsai, Yu-Ju Lin, Hong-Ren Yu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
maternal high-fat
metformin
placenta
steatosis
DOHaD
Online Access:https://www.mdpi.com/1422-0067/23/22/14239

Internet

https://www.mdpi.com/1422-0067/23/22/14239

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