How Does Replacement of the Axial Histidine Ligand in Cytochrome <i>c</i> Peroxidase by N<sub>δ</sub>-Methyl Histidine Affect Its Properties and Functions? A Computational Study

How Does Replacement of the Axial Histidine Ligand in Cytochrome <i>c</i> Peroxidase by N<sub>δ</sub>-Methyl Histidine Affect Its Properties and Functions? A Computational Study

Heme peroxidases have important functions in nature related to the detoxification of H<sub>2</sub>O<sub>2</sub>. They generally undergo a catalytic cycle where, in the first stage, the iron(III)–heme–H<sub>2</sub>O<sub>2</sub> complex is converted into...

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Bibliographic Details
Main Authors: Calvin W. Z. Lee, M. Qadri E. Mubarak, Anthony P. Green, Sam P. de Visser
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
density functional theory
enzyme models
epoxidation
hydroxylation
heme enzymes
peroxidases
Online Access:https://www.mdpi.com/1422-0067/21/19/7133

Internet

https://www.mdpi.com/1422-0067/21/19/7133

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