Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo.

Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo.

In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS. The iNOS inhibitory activity of the hit compounds was characterized using cellular assays and an in vivo zebrafish larvae model. The natural product-like com...

Full description

Bibliographic Details
Main Authors: Hai-Jing Zhong, Li-Juan Liu, Cheong-Meng Chong, Lihua Lu, Modi Wang, Daniel Shiu-Hin Chan, Philip Wai Hong Chan, Simon Ming-Yuen Lee, Dik-Lung Ma, Chung-Hang Leung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3972188?pdf=render

Internet

http://europepmc.org/articles/PMC3972188?pdf=render

Similar Items