Polygenic power calculator: Statistical power and polygenic prediction accuracy of genome-wide association studies of complex traits

Power calculation is a necessary step when planning genome-wide association studies (GWAS) to ensure meaningful findings. Statistical power of GWAS depends on the genetic architecture of phenotype, sample size, and study design. While several computer programs have been developed to perform power ca...

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Bibliographic Details
Main Authors: Tian Wu, Zipeng Liu, Timothy Shin Heng Mak, Pak Chung Sham
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.989639/full