LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473

LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473

Multiple myeloma (MM) is a highly heterogeneous hematological malignancy originating from B lymphocytes, with a high recurrence rate primarily due to drug resistance. 2-((1H-indol-3-yl)methyl)-3-((3-((1H-indol-3-yl)methyl)-1H-indol-2-yl)methyl)-1H-indole (LTe2), a tetrameric indole oligomer, possess...

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Bibliographic Details
Main Authors: Yuanjiao Zhang, Jiacheng Qian, Mingmei Jiang, Shu Yang, Lianxin Zhou, Qin Zhang, Liping Lin, Ye Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
indole oligomer
LTe2
Akt
phosphorylation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1269670/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1269670/full

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