Autophagy facilitates intracellular survival of pathogenic rickettsiae in macrophages via evasion of autophagosomal maturation and reduction of microbicidal pro-inflammatory IL-1 cytokine responses

Autophagy facilitates intracellular survival of pathogenic rickettsiae in macrophages via evasion of autophagosomal maturation and reduction of microbicidal pro-inflammatory IL-1 cytokine responses

ABSTRACT The genus Rickettsia is comprised of obligate intracellular bacterial parasites of a wide range of arthropod and vertebrate hosts. Some Rickettsia species (spp.) are responsible for serious human diseases globally. One interesting feature of these stealthy group of pathogens is their abilit...

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Bibliographic Details
Main Authors: Oliver H. Voss, Hodalis Gaytan, Saif Ullah, Mohammad Sadik, Imran Moin, M. Sayeedur Rahman, Abdu F. Azad
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
R. typhi
R. rickettsii
R. montanensis
autophagy
IL-1α
IL-1β
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02791-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.02791-23

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