Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells

Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells

Mammaglobin-A (MamA) is overexpressed in 40–80% of all human breast cancers. Recent phase I clinical trials of the MamA DNA vaccine showed encouraging safety outcomes. However, this vaccine elicited only a modest increase in MamA specific CD8+T lymphocyte (CTL) activation. As vaccine adjuv...

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Bibliographic Details
Main Authors: Duaa Babaer, Suneetha Amara, Brenda S. McAdory, Owen Johnson, Elbert L. Myles, Roy Zent, Jeffrey C. Rathmell, Venkataswarup Tiriveedhi
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
breast cancer
mammaglobin-A
cancer vaccine
adjuvant
synthetic oligonucleotide
toll-like receptor (TLR)
Online Access:https://www.mdpi.com/2072-6694/11/5/672

Internet

https://www.mdpi.com/2072-6694/11/5/672

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