RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Melanoma is a dangerous form of skin cancer, making it important to investigate new mechanisms and approaches to enhance the effectiveness of treatment. Here, we establish a positive correlation between the human rhomboid family-1 (RHBDF1) protein and melanoma malignancy. We demonstrate that the mel...

Full description

Bibliographic Details
Main Authors: Lei Wang, Yuan-Yuan Song, Yan Wang, Xiu-Xiu Liu, Yi-Lun Yin, Shan Gao, Fan Zhang, Lu-Yuan Li, Zhi-Song Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Pharmacological Research
Subjects:
Melanoma
Immunotherapy
Glycolysis
RHBDF1
GPI
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003511

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823003511

Similar Items