Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents

Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents

Bispecific agents are a rapidly growing class of cancer therapeutics, and immune targeted bispecific agents have the potential to expand functionality well beyond monoclonal antibody agents. Humabodies⁎⁎ Humabody® is a registered trademark of Crescendo Biologics Ltd. are fully human single domain an...

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Bibliographic Details
Main Authors: Anna Kopp, Hyeyoung Kwon, Colette Johnston, Steven Vance, James Legg, Laurie Galson-Holt, Greg M. Thurber
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Bispecific antibodies
Tumoral distribution
T-cell activating agents
Single domain antibodies
Heterotypic spheroids
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000854

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http://www.sciencedirect.com/science/article/pii/S1476558623000854

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