Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor
Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulati...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.587386/full |
| _version_ | 1818242150864781312 |
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| author | Rahul Mal Alexa Magner Joel David Jharna Datta Meghna Vallabhaneni Mahmoud Kassem Mahmoud Kassem Jasmine Manouchehri Natalie Willingham Daniel Stover Daniel Stover Jeffery Vandeusen Jeffery Vandeusen Sagar Sardesai Sagar Sardesai Nicole Williams Nicole Williams Robert Wesolowski Robert Wesolowski Maryam Lustberg Maryam Lustberg Ramesh K. Ganju Bhuvaneswari Ramaswamy Bhuvaneswari Ramaswamy Mathew A. Cherian Mathew A. Cherian |
| author_facet | Rahul Mal Alexa Magner Joel David Jharna Datta Meghna Vallabhaneni Mahmoud Kassem Mahmoud Kassem Jasmine Manouchehri Natalie Willingham Daniel Stover Daniel Stover Jeffery Vandeusen Jeffery Vandeusen Sagar Sardesai Sagar Sardesai Nicole Williams Nicole Williams Robert Wesolowski Robert Wesolowski Maryam Lustberg Maryam Lustberg Ramesh K. Ganju Bhuvaneswari Ramaswamy Bhuvaneswari Ramaswamy Mathew A. Cherian Mathew A. Cherian |
| author_sort | Rahul Mal |
| collection | DOAJ |
| description | Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. ERβ has multiple isoforms that show differing association with prognosis. Expression levels of the full length ERβ1 isoform are often lower in aggressive cancers as compared to normal tissue. High ERβ1 expression is associated with improved overall survival in women with breast cancer. The promise of ERβ activation, as a potential targeted therapy, is based on concurrent activation of multiple tumor suppressor pathways with few side effects compared to chemotherapy. Thus, ERβ is a nuclear receptor with broad-spectrum tumor suppressor activity, which could serve as a potential treatment target in a variety of human cancers including breast cancer. Further development of highly selective agonists that lack ERα agonist activity, will be necessary to fully harness the potential of ERβ. |
| first_indexed | 2024-12-12T13:40:40Z |
| format | Article |
| id | doaj.art-e10d89465998455496bb1a64694d5fae |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T13:40:40Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e10d89465998455496bb1a64694d5fae2022-12-22T00:22:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.587386587386Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor SuppressorRahul Mal0Alexa Magner1Joel David2Jharna Datta3Meghna Vallabhaneni4Mahmoud Kassem5Mahmoud Kassem6Jasmine Manouchehri7Natalie Willingham8Daniel Stover9Daniel Stover10Jeffery Vandeusen11Jeffery Vandeusen12Sagar Sardesai13Sagar Sardesai14Nicole Williams15Nicole Williams16Robert Wesolowski17Robert Wesolowski18Maryam Lustberg19Maryam Lustberg20Ramesh K. Ganju21Bhuvaneswari Ramaswamy22Bhuvaneswari Ramaswamy23Mathew A. Cherian24Mathew A. Cherian25Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesComprehensive Cancer Center, The Ohio State University, Columbus, OH, United StatesStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, United StatesEstrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the transcription of a large number of genes, thus modulating critical physiologic processes. ERβ has multiple isoforms that show differing association with prognosis. Expression levels of the full length ERβ1 isoform are often lower in aggressive cancers as compared to normal tissue. High ERβ1 expression is associated with improved overall survival in women with breast cancer. The promise of ERβ activation, as a potential targeted therapy, is based on concurrent activation of multiple tumor suppressor pathways with few side effects compared to chemotherapy. Thus, ERβ is a nuclear receptor with broad-spectrum tumor suppressor activity, which could serve as a potential treatment target in a variety of human cancers including breast cancer. Further development of highly selective agonists that lack ERα agonist activity, will be necessary to fully harness the potential of ERβ.https://www.frontiersin.org/articles/10.3389/fonc.2020.587386/fullESR1ESR2ERαERβbreast cancer |
| spellingShingle | Rahul Mal Alexa Magner Joel David Jharna Datta Meghna Vallabhaneni Mahmoud Kassem Mahmoud Kassem Jasmine Manouchehri Natalie Willingham Daniel Stover Daniel Stover Jeffery Vandeusen Jeffery Vandeusen Sagar Sardesai Sagar Sardesai Nicole Williams Nicole Williams Robert Wesolowski Robert Wesolowski Maryam Lustberg Maryam Lustberg Ramesh K. Ganju Bhuvaneswari Ramaswamy Bhuvaneswari Ramaswamy Mathew A. Cherian Mathew A. Cherian Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor Frontiers in Oncology ESR1 ESR2 ERα ERβ breast cancer |
| title | Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor |
| title_full | Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor |
| title_fullStr | Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor |
| title_full_unstemmed | Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor |
| title_short | Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor |
| title_sort | estrogen receptor beta erβ a ligand activated tumor suppressor |
| topic | ESR1 ESR2 ERα ERβ breast cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.587386/full |
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