Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events

Patatin‐like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events

Single nucleotide polymorphism (SNP) rs738409 C>G in the patatin‐like phospholipase domain containing 3 (PNPLA3) gene results in an amino acid exchange from isoleucin to methionine at position I148M of PNPLA3. The expression of this loss‐of‐function mutation leads to impaired hepatocellular trigl...

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Bibliographic Details
Main Authors: Sabrina Rüschenbaum, Katharina Schwarzkopf, Mireen Friedrich‐Rust, Florian Seeger, Fabian Schoelzel, Yolanda Martinez, Stefan Zeuzem, Jörg Bojunga, Christian M. Lange
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2018-07-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1183

Internet

https://doi.org/10.1002/hep4.1183

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