Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis

Endogenous SIRT6 in platelets negatively regulates platelet activation and thrombosis

Thromboembolism resulting from platelet dysfunction constitutes a significant contributor to the development of cardiovascular disease. Sirtuin 6 (SIRT6), an essential NAD+-dependent enzyme, has been linked to arterial thrombosis when absent in endothelial cells. In the present study, we have confir...

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Bibliographic Details
Main Authors: Yanli Liu, Tao Wang, Qilong Zhou, Guang Xin, Hai Niu, Fan Li, Yilan Wang, Shiyi Li, Yuman Dong, Kun Zhang, Lijuan Feng, Wei Fu, Boli Zhang, Wen Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Pharmacology
Subjects:
platelet activation
cardiovascular-related disease
SIRT6
thrombosis
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1268708/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1268708/full

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