Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model.

Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model.

Cytotoxic chemotherapy can be very effective for the treatment of cancer but toxicity on normal tissues often limits patient tolerance and often causes long-term adverse effects. The objective of this study was to assist in the preclinical development of using modified, non-living bacterially-derive...

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Bibliographic Details
Main Authors: Jennifer A MacDiarmid, Veronika Langova, Dale Bailey, Scott T Pattison, Stacey L Pattison, Neil Christensen, Luke R Armstrong, Vatsala N Brahmbhatt, Katarzyna Smolarczyk, Matthew T Harrison, Marylia Costa, Nancy B Mugridge, Ilya Sedliarou, Nicholas A Grimes, Debra L Kiss, Bruce Stillman, Christine L Hann, Gary L Gallia, Robert M Graham, Himanshu Brahmbhatt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4822833?pdf=render

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http://europepmc.org/articles/PMC4822833?pdf=render

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