Differential Effects of Dietary Macronutrients on the Development of Oncogenic KRAS-Mediated Pancreatic Ductal Adenocarcinoma

Differential Effects of Dietary Macronutrients on the Development of Oncogenic KRAS-Mediated Pancreatic Ductal Adenocarcinoma

KRAS mutations are prevalent in patients with pancreatic ductal adenocarcinoma (PDAC) and are critical to fostering tumor growth in part by aberrantly rewiring glucose, amino acid, and lipid metabolism. Obesity is a modifiable risk factor for pancreatic cancer. Corroborating this epidemiological obs...

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Bibliographic Details
Main Authors: Liang Zhu, Juntao Ji, Jianjia Ma, Dan Wang, Muyun Liu, James Xianxing Du, Rong Chen, Wei Hou, James L. Abbruzzese, Craig D. Logsdon, Vincent W. Yang, Yongde Luo, Weiqin Lu
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
pancreatic cancer
KRAS
macronutrients
high-carbohydrate diet
inflammation
high-protein diet
Online Access:https://www.mdpi.com/2072-6694/14/11/2723

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https://www.mdpi.com/2072-6694/14/11/2723

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