A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults
An adequate nutritional intake is recommended for the prevention of physical frailty and sarcopenia. In particular, medium-chain fatty acids (MCFAs) are reportedly important for muscle strength in nursing home residents. However, the effects of MCFAs on healthy adults at risk for frailty remain unkn...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/14/3275 |
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| author | Keiichi Kojima Haruna Ishikawa Shinji Watanabe Naohisa Nosaka Tatsushi Mutoh |
| author_facet | Keiichi Kojima Haruna Ishikawa Shinji Watanabe Naohisa Nosaka Tatsushi Mutoh |
| author_sort | Keiichi Kojima |
| collection | DOAJ |
| description | An adequate nutritional intake is recommended for the prevention of physical frailty and sarcopenia. In particular, medium-chain fatty acids (MCFAs) are reportedly important for muscle strength in nursing home residents. However, the effects of MCFAs on healthy adults at risk for frailty remain unknown. Hence, a randomized, placebo-controlled study was conducted to investigate the effects of 12 weeks of medium-chain triglycerides (MCTs) intake and walking on muscle mass and function in healthy, sedentary, middle-aged and older adults with a low body mass index. Three MCT intake groups with different amounts of octanoic and decanoic acid intake were compared with a control group. After 12 weeks, knee extension strength increased in all groups, with the increases in all MCT intake groups being significantly higher than those in the control group (<i>p</i> < 0.05). Grip strength significantly increased from baseline in the MCT 6 g/day intake group (<i>p</i> < 0.05). The combination of aerobic exercise and MCT intake may be effective in preventing decline in muscle strength and promoting increase in muscle strength as they can improve muscle energy production, thereby contributing to the maintenance of good health for middle-aged and older adults at high risk for frailty and sarcopenia. |
| first_indexed | 2024-03-11T00:46:25Z |
| format | Article |
| id | doaj.art-e11c32445092473a8febc605ef353185 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:46:25Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e11c32445092473a8febc605ef3531852023-11-18T20:49:45ZengMDPI AGNutrients2072-66432023-07-011514327510.3390/nu15143275A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older AdultsKeiichi Kojima0Haruna Ishikawa1Shinji Watanabe2Naohisa Nosaka3Tatsushi Mutoh4Central Research Laboratory, The Nisshin OilliO Group, Ltd., Yokohama 235-8558, Kanagawa, JapanCentral Research Laboratory, The Nisshin OilliO Group, Ltd., Yokohama 235-8558, Kanagawa, JapanCentral Research Laboratory, The Nisshin OilliO Group, Ltd., Yokohama 235-8558, Kanagawa, JapanCentral Research Laboratory, The Nisshin OilliO Group, Ltd., Yokohama 235-8558, Kanagawa, JapanDepartment of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8574, Miyagi, JapanAn adequate nutritional intake is recommended for the prevention of physical frailty and sarcopenia. In particular, medium-chain fatty acids (MCFAs) are reportedly important for muscle strength in nursing home residents. However, the effects of MCFAs on healthy adults at risk for frailty remain unknown. Hence, a randomized, placebo-controlled study was conducted to investigate the effects of 12 weeks of medium-chain triglycerides (MCTs) intake and walking on muscle mass and function in healthy, sedentary, middle-aged and older adults with a low body mass index. Three MCT intake groups with different amounts of octanoic and decanoic acid intake were compared with a control group. After 12 weeks, knee extension strength increased in all groups, with the increases in all MCT intake groups being significantly higher than those in the control group (<i>p</i> < 0.05). Grip strength significantly increased from baseline in the MCT 6 g/day intake group (<i>p</i> < 0.05). The combination of aerobic exercise and MCT intake may be effective in preventing decline in muscle strength and promoting increase in muscle strength as they can improve muscle energy production, thereby contributing to the maintenance of good health for middle-aged and older adults at high risk for frailty and sarcopenia.https://www.mdpi.com/2072-6643/15/14/3275medium-chain fatty acidsmedium-chain triglyceridesmuscle strengthwalking abilityfrailtysarcopenia |
| spellingShingle | Keiichi Kojima Haruna Ishikawa Shinji Watanabe Naohisa Nosaka Tatsushi Mutoh A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults Nutrients medium-chain fatty acids medium-chain triglycerides muscle strength walking ability frailty sarcopenia |
| title | A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults |
| title_full | A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults |
| title_fullStr | A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults |
| title_full_unstemmed | A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults |
| title_short | A Randomized, Double-Blind, Controlled Trial Assessing If Medium-Chain Triglycerides in Combination with Moderate-Intensity Exercise Increase Muscle Strength in Healthy Middle-Aged and Older Adults |
| title_sort | randomized double blind controlled trial assessing if medium chain triglycerides in combination with moderate intensity exercise increase muscle strength in healthy middle aged and older adults |
| topic | medium-chain fatty acids medium-chain triglycerides muscle strength walking ability frailty sarcopenia |
| url | https://www.mdpi.com/2072-6643/15/14/3275 |
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