Dopamine-Mediated Major Depressive Disorder in the Neural Circuit of Ventral Tegmental Area-Nucleus Accumbens-Medial Prefrontal Cortex: From Biological Evidence to Computational Models

Dopamine-Mediated Major Depressive Disorder in the Neural Circuit of Ventral Tegmental Area-Nucleus Accumbens-Medial Prefrontal Cortex: From Biological Evidence to Computational Models

Major depressive disorder (MDD) is a serious psychiatric disorder, with an increasing incidence in recent years. The abnormal dopaminergic pathways of the midbrain cortical and limbic system are the key pathological regions of MDD, particularly the ventral tegmental area- nucleus accumbens- medial p...

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Bibliographic Details
Main Authors: Yuanxi Li, Bing Zhang, Xiaochuan Pan, Yihong Wang, Xuying Xu, Rubin Wang, Zhiqiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
major depressive disorder
NAc-mPFC-VTA circuit
dopamine
Hodgkin-Huxley (HH) model
dynamical receptor binding model
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.923039/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.923039/full

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