Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway.

We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed for their in vitro anticancer activity against four cancer cell lines; A549, Caco-2, HepG-2 and MDA-MB-231. Compound 14a showed the most potent effects...

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Bibliographic Details
Main Authors: Mohammed S Taghour, Hazem Elkady, Wagdy M Eldehna, Nehal El-Deeb, Ahmed M Kenawy, Eslam B Elkaeed, Bshra A Alsfouk, Mohamed S Alesawy, Dalal Z Husein, Ahmed M Metwaly, Ibrahim H Eissa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0272362