Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

Abstract RAS genes are the most frequently mutated oncogenes and play critical roles in the development and progression of malignancies. The mutation, isoform (KRAS, HRAS, and NRAS), position, and type of substitution vary depending on the tissue types. Despite decades of developing RAS‐targeted the...

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Bibliographic Details
Main Authors: Hang Yang, Xinyi Zhou, Dongliang Fu, Chenqin Le, Jiafeng Wang, Quan Zhou, Xiangrui Liu, Ying Yuan, Kefeng Ding, Qian Xiao
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Cancer Communications
Subjects:
RAS mutation
Signal transduction
RAS‐targeted therapy
Combination therapy
Immunotherapy
Cancer metabolism
Online Access:https://doi.org/10.1002/cac2.12377

Internet

https://doi.org/10.1002/cac2.12377

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