Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43

Live-Cell Assays for Cell Stress Responses Reveal New Patterns of Cell Signaling Caused by Mutations in Rhodopsin, α-Synuclein and TDP-43

Many neurodegenerative diseases induce high levels of sustained cellular stress and alter a number of cellular processes. To examine how different mutations associated with neurodegenerative disease affect cell stress and signaling, we created live-cell assays for endoplasmic reticulum (ER)-mediated...

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Bibliographic Details
Main Authors: Kevin M. Harlen, Elizabeth C. Roush, Joseph E. Clayton, Scott Martinka, Thomas E. Hughes
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neurodegeneration
Parkinson’s disease
unfolded protein response
retinitis pigmentosa
cAMP
Ca2+
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00535/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00535/full

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