Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity

Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity

ABSTRACTAcetyl-CoA carboxylases (ACCs) convert acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and autotrophic carbon fixation pathways. Three functionally distinct components, biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and carboxyltransferase (CT), are either...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Jiejie Shen, Wenping Wu, Kangle Wang, Jingyi Wu, Bing Liu, Chunyang Li, Zijun Gong, Xin Hong, Han Fang, Xingwei Zhang, Xiaoling Xu
Format: Artikel
Sprache:English
Veröffentlicht: American Society for Microbiology 2024-05-01
Schriftenreihe:mBio
Schlagworte:
acetyl-CoA carboxylase
biotin carboxylase
biotin carboxyl carrier protein
carboxyltransferase
3-hydroxypropionate
Online Zugang:https://journals.asm.org/doi/10.1128/mbio.03414-23

Online

https://journals.asm.org/doi/10.1128/mbio.03414-23

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